阿霉素用于成人急性淋巴细胞白血病的联合化疗：西南肿瘤协作组的一项研究

Adriamycin in combination chemotherapy of adult acute lymphoblastic leukemia: a Southwest Oncology Group study.

作者信息

Shaw M T, Raab S O

出版信息

Med Pediatr Oncol. 1977;3(3):261-6. doi: 10.1002/mpo.2950030307.

Abstract

Eighteen (72%) of 25 evaluable and previously untreated patients with adult acute lymphoblastic leukemia entered complete remission (CR) following induction therapy with adriamycin, vincristine, and prednisone in a Southwest Oncology Group study. Remission maintenance therapy with methotrexate and 6-mercaptopurine resulted in a median duration of CR of 10.2 months. The addition of Adriamycin to prednisone and vincristine may be beneficial in slow responders or nonresponders to these two drugs and in patients with initially high peripheral blood blast counts.

摘要

在西南肿瘤协作组的一项研究中，25例可评估且先前未接受过治疗的成年急性淋巴细胞白血病患者中，18例（72%）在接受阿霉素、长春新碱和泼尼松诱导治疗后进入完全缓解（CR）。使用甲氨蝶呤和6-巯基嘌呤进行缓解期维持治疗，CR的中位持续时间为10.2个月。在泼尼松和长春新碱治疗反应缓慢或无反应的患者以及外周血原始细胞计数最初较高的患者中，添加阿霉素可能有益。