Liu E H, Shailaja S, Koh S C, Lee T L
Departments of Anaesthesia and Obstetrics and Gynaecology, National University Hospital, Singapore.
Anesth Analg. 2000 Feb;90(2):333-6. doi: 10.1097/00000539-200002000-00018.
The Thrombelastograph((R)) test (TEG; Haemoscope Corporation, Skokie, IL) was used to assess the effects of midtrimester and final-trimester amniotic fluid (AF) on whole blood coagulation. Different volumes of midtrimester and final-trimester AF were added to whole blood from nonpregnant volunteers in a series of TEG tests. The addition of both midtrimester and final-trimester AF resulted in significant decreases in reaction time (P < 0.001) and time from reaction to a fixed level of clot firmness (P < 0.05) and significant increases in angle (P < 0.05) and coagulation index (P < 0.05) values. This reflects accelerated clot initiation and propagation. There was no significant change in the maximal amplitude or % lysis at 30 and 60 min with the addition of either midtrimester or final-trimester AF. There was no significant difference between the effects of midtrimester and final-trimester AF on whole blood TEG. TEG may be an additional useful tool in the treatment of coagulopathy in AF embolism.
We used the Thrombelastograph((R)) test (Haemoscope Corporation, Skokie, IL) to assess the effects of midtrimester and final-trimester amniotic fluid (AF) on whole blood coagulation. Results demonstrate that AF accelerates clot initiation and propagation. The Thrombelastograph((R)) test may be useful in assessing coagulopathy in patients with AF embolism.
使用血栓弹力图（TEG；美国伊利诺伊州斯科基市血液显微镜公司）测试来评估孕中期和孕晚期羊水（AF）对全血凝血的影响。在一系列TEG测试中，将不同体积的孕中期和孕晚期羊水添加到非妊娠志愿者的全血中。添加孕中期和孕晚期羊水均导致反应时间显著缩短（P<0.001）以及从反应到达到固定血凝块强度水平的时间显著缩短（P<0.05），同时角度（P<0.05）和凝血指数（P<0.05）值显著增加。这反映了凝血启动和传播加速。添加孕中期或孕晚期羊水后，30分钟和60分钟时的最大振幅或溶解百分比没有显著变化。孕中期和孕晚期羊水对全血TEG的影响之间没有显著差异。TEG可能是治疗羊水栓塞凝血病的另一种有用工具。
我们使用血栓弹力图（美国伊利诺伊州斯科基市血液显微镜公司）测试来评估孕中期和孕晚期羊水对全血凝血的影响。结果表明，羊水可加速凝血启动和传播。血栓弹力图测试可能有助于评估羊水栓塞患者的凝血病。
