Efficient Hydrolysis of RNA by a PNA - Diethylenetriamine Adduct.
作者信息
Verheijen JC, Deiman BA, Yeheskiely E
机构信息
Leiden Institute of Chemistry Gorlaeus Laboratories, P.O. Box 9502, 2300 RA Leiden (The Netherlands).
出版信息
Angew Chem Int Ed Engl. 2000 Jan;39(2):369-372. doi: 10.1002/(sici)1521-3773(20000117)39:2<369::aid-anie369>3.0.co;2-a.
Abstract
The introduction of a urea bond linking a protected diethylenetriamine (DETA) unit and the terminal amino group of a resin-bound peptide nucleic acid (PNA) decamer gave access to a PNA - DETA adduct (shown here), which hydrolyzed the target 25-mer RNA rapidly and sequence specifically.
摘要
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