Demir R, Bodur H, Tokoğlu F, Olcay I, Uçan H, Borman P
Department of Physical Medicine and Rehabilitation, Numune Education and Research Hospital, Ankara, Turkey.
Rheumatol Int. 1999;19(1-2):19-22. doi: 10.1007/s002960050093.
Pulmonary involvement is one of the most common extra-articular manifestations of rheumatoid arthritis (RA). The aim of this prospective study was to assess pulmonary involvement with high resolution computerized tomography (HRCT) in lifelong non-smoking patients with RA. Twenty-six female and eight male patients with a mean age of 45.26 +/- 11.6 years and without any evidence or symptoms of a respiratory disease were included in the study. Data were obtained regarding duration of disease, clinical symptoms and disease activity parameters. Standard chest roentgenographs, pulmonary function tests (PFT) and HRCT were performed. PFT was abnormal in eight (23.5%) and HRCT was abnormal in 23 patients (68%). The most frequent abnormalities obtained on HRCT were interstitial involvement including septal and peribronchial thickening and fibronodular infiltration, which were found in 23 patients, and bronchiectasis was found in nine patients. Using a highly sensitive technique such as HRCT the incidence of pulmonary abnormalities in asymptomatic rheumatoid patients may be much higher than previously reported.
肺部受累是类风湿关节炎（RA）最常见的关节外表现之一。这项前瞻性研究的目的是通过高分辨率计算机断层扫描（HRCT）评估终身不吸烟的RA患者的肺部受累情况。本研究纳入了26名女性和8名男性患者，平均年龄为45.26±11.6岁，且无任何呼吸系统疾病的证据或症状。获取了有关疾病持续时间、临床症状和疾病活动参数的数据。进行了标准胸部X线片、肺功能测试（PFT）和HRCT检查。8例（23.5%）患者的PFT异常，23例（68%）患者的HRCT异常。HRCT上最常见的异常是间质性病变，包括小叶间隔和支气管周围增厚以及纤维结节浸润，23例患者出现此类病变，9例患者发现支气管扩张。使用HRCT这种高灵敏度技术，无症状类风湿患者肺部异常的发生率可能比先前报道的要高得多。
