组蛋白乙酰转移酶复合物及其与转录的联系。
Histone acetyltransferase complexes and their link to transcription.
作者信息
Howe L, Brown C E, Lechner T, Workman J L
机构信息
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802-4500, USA.
出版信息
Crit Rev Eukaryot Gene Expr. 1999;9(3-4):231-43. doi: 10.1615/critreveukargeneexpr.v9.i3-4.80.
Early studies revealing the relationship between the state of histone acetylation and gene transcription were largely indirect. Increasing information regarding the enzymes that catalyze transcription linked acetylation is beginning to clarify this issue. This review attempts to relate previous data regarding the distribution of histone acetylation within different chromatin regions with recent data regarding the substrate specificity, subunit composition, and recruitment of the known histone acetyltransferase complexes.
早期揭示组蛋白乙酰化状态与基因转录之间关系的研究大多是间接的。关于催化转录相关乙酰化的酶的信息越来越多，这开始澄清这个问题。本综述试图将先前关于不同染色质区域内组蛋白乙酰化分布的数据与最近关于已知组蛋白乙酰转移酶复合物的底物特异性、亚基组成和募集的数据联系起来。
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