Chan C K, Leung C C, Tam C M, Yu T S, Wong T W
Tuberculosis and Chest Service, Department of Health, Hong Kong, China.
J Occup Environ Med. 2000 Jan;42(1):69-75. doi: 10.1097/00043764-200001000-00016.
To examine any association between silicosis and lung cancer, the clinic records of a cohort of 1502 silicotic workers diagnosed after 1981 were reviewed. All of the essential data, including occupational exposure, smoking habits, radiographic extent of silicosis, and vital status of each subject, were noted. The standardized mortality ratio for various causes of death was calculated. Thirty-three patients died from lung cancer, giving a standardized mortality ratio of 1.94 (95% confidence interval, 1.35 to 2.70). However, smoking accounted for most of the excess of lung cancer deaths among the silicotic workers in the cohort, and no consistent relationship between lung cancer mortality risk and either duration of exposure to silica dust or severity of silicosis was observed. There is no conclusive evidence in our data to support the hypothesis that lung cancer may be associated with silicosis.
为了研究矽肺与肺癌之间的任何关联，我们回顾了1981年以后确诊的1502名矽肺工人队列的临床记录。记录了所有基本数据，包括职业暴露、吸烟习惯、矽肺的影像学范围以及每个受试者的生命状态。计算了各种死因的标准化死亡比。33名患者死于肺癌，标准化死亡比为1.94（95%置信区间，1.35至2.70）。然而，吸烟是该队列中矽肺工人肺癌死亡超额的主要原因，并且未观察到肺癌死亡风险与二氧化硅粉尘暴露时间或矽肺严重程度之间存在一致关系。我们的数据中没有确凿证据支持肺癌可能与矽肺相关的假设。
