多发性视网膜小动脉闭塞与原发性抗磷脂综合征和凝血因子V莱顿突变并存相关。
Multiple retinal arteriolar occlusions associated with coexisting primary antiphospholipid syndrome and factor V Leiden mutation.
作者信息
Dori D, Beiran I, Gelfand Y, Lanir N, Scharf J, Miller B, Brenner B
机构信息
Department of Ophthalmology, Rambam Medical Center, Haifa, Israel.
出版信息
Am J Ophthalmol. 2000 Jan;129(1):106-8. doi: 10.1016/s0002-9394(99)00278-0.
PURPOSE
To investigate a case of a young woman with both primary antiphospholipid syndrome and factor V Leiden mutation who developed multiple retinal arteriolar occlusions.
METHOD
Case report of a 25-year-old woman with history and laboratory tests confirming the diagnosis of both primary antiphospholipid syndrome and factor V Leiden mutation who presented with blurred vision in both eyes.
RESULTS
Multiple retinal arteriolar occlusions were observed in both of her eyes. The patient was treated first with heparin and then with warfarin.
CONCLUSIONS
Primary antiphospholipid syndrome and factor V Leiden mutation, as well as other forms of thrombophilia, should be considered in the differential diagnosis of unexplained retinal vascular occlusions. The coexistence of several thrombophilic disorders may carry a particularly high risk for thrombotic manifestations.
目的
调查一名患有原发性抗磷脂综合征和凝血因子V莱顿突变的年轻女性发生多发性视网膜小动脉阻塞的病例。
方法
对一名25岁女性的病例报告，其病史和实验室检查证实诊断为原发性抗磷脂综合征和凝血因子V莱顿突变，该患者双眼出现视力模糊。
结果
在她的双眼均观察到多发性视网膜小动脉阻塞。患者首先接受肝素治疗，然后接受华法林治疗。
结论
在不明原因的视网膜血管阻塞的鉴别诊断中，应考虑原发性抗磷脂综合征和凝血因子V莱顿突变以及其他形式的血栓形成倾向。几种血栓形成性疾病的共存可能会带来特别高的血栓形成表现风险。
Zotero 插件