Meissner M, Stark K, Cresnar B, Kirk D L, Schmitt R
Lehrstuhl für Genetik, Universität Regensburg, Germany.
Curr Genet. 1999 Dec;36(6):363-70. doi: 10.1007/s002940050511.
In Volvox carteri, regA acts as a master gene to suppress all germ cell functions in somatic cells. Its product, RegA, has features of a transcriptional repressor. Here we report cDNA sequences representing 15 nuclear genes with properties expected of RegA targets: they are expressed strongly in germ cells and in regA-, but not regA+, somatic cells. Two of them encode polypeptides with no recognizable features, but ten (like three previously sequenced ones) encode chloroplast proteins of known function, and the remaining three encode putative chloroplast proteins of unknown function. This suggests that RegA blocks reproductive development in somatic cells by preventing chloroplast biogenesis, thereby making it impossible for the cells to grow enough to reproduce.
在团藻中，regA作为一个主控基因，抑制体细胞中的所有生殖细胞功能。其产物RegA具有转录抑制因子的特征。在此，我们报告了代表15个核基因的cDNA序列，这些基因具有RegA靶标的预期特性：它们在生殖细胞和regA - 而非regA + 的体细胞中强烈表达。其中两个编码没有可识别特征的多肽，但十个（如之前测序的三个）编码已知功能的叶绿体蛋白，其余三个编码功能未知的假定叶绿体蛋白。这表明RegA通过阻止叶绿体生物发生来阻断体细胞中的生殖发育，从而使细胞无法生长到足以繁殖的程度。
