Maier W, Rietschel M, Lichtermann D, Wildenauer D B
Klinik für Psychiatrie und Psychotherapie, Universität Bonn, Germany.
Eur Arch Psychiatry Clin Neurosci. 1999;249 Suppl 4:57-61. doi: 10.1007/pl00014186.
Schizophrenia is a genetically influenced disease with a broad and heterogeneous phenotype transmitted in families. Of particular interest is the familial-genetic relationship between schizophrenia and affective disorders. Taking advantage of refined epidemiological methods, the dichotomy between both groups of disorders is not less consistently found than expected. Recently, linkage studies identified multiple candidate regions for susceptibility genes for each of both disorders. Several of these candidate regions for schizophrenia are overlapping with candidate regions for bipolar disorder. Thus, the hypothesis of an etiological dichotomy of schizophrenia and affective disorders faces a new challenge.
精神分裂症是一种受遗传影响的疾病，具有广泛且异质性的表型，可在家族中传递。特别令人感兴趣的是精神分裂症与情感障碍之间的家族遗传关系。利用精密的流行病学方法，两组疾病之间的二分法并不比预期的少。最近，连锁研究确定了这两种疾病各自的多个易感基因候选区域。其中几个精神分裂症的候选区域与双相情感障碍的候选区域重叠。因此，精神分裂症和情感障碍病因二分法的假设面临新的挑战。
