左心室驱动的冠状静脉窦逆行灌注可减小急性缺血猪的梗死面积。

LV-powered coronary sinus retroperfusion reduces infarct size in acutely ischemic pigs.

作者信息

Martin J S, Byrne J G, Ghez O Y, Sayeed-Shah U, Grachev S D, Laurence R G, Cohn L H

机构信息

Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

Ann Thorac Surg. 2000 Jan;69(1):84-9. doi: 10.1016/s0003-4975(99)00865-6.

DOI:10.1016/s0003-4975(99)00865-6

PMID:10654492

Abstract

BACKGROUND

We developed a prosthetic left ventricle (LV) to coronary sinus (CS) shunt (LVCSS) that is autoregulating and provides LV-powered retrograde perfusion of the coronary sinus.

METHODS

Each of 20 Yorkshire pigs underwent 1 hour of left anterior descending diagonal artery occlusion followed by 3 hours of reperfusion. The controls (n = 5) did not have shunt treatment. The LVCSS group (n = 9) underwent shunt treatment during the ischemic period. The LVCSS with partial coronary sinus occlusion (PCSO) group (LVCSS+PCSO, n = 6) underwent shunt treatment and PCSO during the ischemic period. Vital staining and planimetry techniques were used to determine the area at risk for infarction and the area of necrosis.

RESULTS

The area at risk was not significantly different among groups. The area of necrosis was decreased by 53% in the LVCSS group and by 73% in the LVCSS+PCSO group when compared to controls (p<0.01 among all groups).

CONCLUSIONS

The LVCSS reduces infarct size in pigs after acute coronary artery occlusion. The addition of PCSO to LVCSS further improves myocardial salvage.

摘要

背景

我们研发了一种从人工左心室（LV）到冠状窦（CS）的分流装置（LVCSS），该装置具有自动调节功能，并能提供由左心室驱动的冠状窦逆行灌注。

方法

20只约克郡猪每只都经历了1小时的左前降支对角支动脉闭塞，随后进行3小时的再灌注。对照组（n = 5）未接受分流治疗。LVCSS组（n = 9）在缺血期接受分流治疗。部分冠状窦闭塞的LVCSS组（LVCSS+PCSO，n = 6）在缺血期接受分流治疗和部分冠状窦闭塞。使用活体染色和面积测量技术来确定梗死危险区和坏死面积。