Gonzalez-Lima F, Sadile A G
lnstitute of Neuroscience, Department of Psychology, University of Texas at Austin, 78712, USA.
Neurosci Biobehav Rev. 2000 Jan;24(1):157-60. doi: 10.1016/s0149-7634(99)00049-4.
Genetic rat models are important for research on the neural networks of attention and emotionality. Naples-High Excitability (NHE) rats and Naples Low-Excitability (NLE) rats were investigated with random-bred (NRB) rats as controls. These rat lines were named for their respective behavior on spatial novelty tasks. Quantitative cytochrome oxidase (CO) histochemistry has been demonstrated to reflect long-lasting changes in tissue metabolic capacity. CO metabolic differences between the NLE and NHE were found in the granular cell layer of the outer blade of the dentate gyrus. In addition, NLE showed greater CO activity than NRB in medial frontal cortex, and lower activity in perirhinal cortex (dorsal region). NHE showed greater CO activity than NRB in entorhinal cortex (superficial layers) and lower activities in perirhinal cortex and cortical amygdala. These data support the hypothesis that NLE/NHE rats may be an appropriate model for studying genetically altered limbic regions related to impaired emotional processing. The results support the involvement of limbic circuits in attentive processes and impulsiveness, and support the use of the NLE and NHE strains as animal models of Attention Deficit Hyperactivity Disorder (ADHD) in children.
基因大鼠模型对于注意力和情绪神经网络的研究很重要。以随机繁殖的大鼠（NRB）作为对照，对那不勒斯高兴奋性（NHE）大鼠和那不勒斯低兴奋性（NLE）大鼠进行了研究。这些大鼠品系因其在空间新奇任务中的各自行为而得名。定量细胞色素氧化酶（CO）组织化学已被证明能反映组织代谢能力的长期变化。在齿状回外叶颗粒细胞层中发现了NLE和NHE之间的CO代谢差异。此外，NLE在内侧额叶皮质中的CO活性高于NRB，而在鼻周皮质（背侧区域）中的活性较低。NHE在内嗅皮质（浅层）中的CO活性高于NRB，而在鼻周皮质和皮质杏仁核中的活性较低。这些数据支持了这样一种假设，即NLE/NHE大鼠可能是研究与情绪加工受损相关的基因改变边缘区域的合适模型。结果支持边缘回路参与注意力过程和冲动性，并支持将NLE和NHE品系用作儿童注意力缺陷多动障碍（ADHD）的动物模型。
