改善胱氨酸结石治疗：溶解的体外研究
Improving cystine stone therapy: an in vitro study of dissolution.
作者信息
Heimbach D, Jacobs D, Müller S C, Hesse A
机构信息
Department of Urology, University of Bonn, Germany.
出版信息
Urology. 2000 Jan;55(1):17-21. doi: 10.1016/s0090-4295(99)00386-6.
OBJECTIVES
To perform an in vitro study analyzing the possibilities in therapeutic strategies for an effective treatment of cystine stones.
METHODS
Artificial stones made of cystine [Bon(n)-Stones] with a ball-shaped size of 0.9 cm in diameter were used. Chemolysis of artificial cystine stones with different solvents (artificial urine, physiologic sodium chloride solution, acetylcysteine, tris-(hydroxymethylene)-aminomethane [THAM], and combinations of these) was investigated. An experimental arrangement with computer-assisted online measurement of data simulating the physiologic conditions in the upper urinary tract at varying pH values was used.
RESULTS
All solutions showed a statistical improvement in the solubility of cystine stones compared with artificial urine and physiologic sodium chloride solution. The combination of THAM (pH 10) and 2% acetylcysteine was most effective (1 3.91 +/- 1.73 mg/hr) and demonstrated a 41 -fold higher ability to dissolve cystine calculi compared with artificial urine.
CONCLUSIONS
Our data indicate that local chemolysis with special solutions is an effective treatment modality in cystine stone therapy.
目的
进行一项体外研究，分析有效治疗胱氨酸结石的治疗策略的可能性。
方法
使用直径为0.9厘米的球形胱氨酸人工结石（Bon(n)结石）。研究了不同溶剂（人工尿液、生理氯化钠溶液、乙酰半胱氨酸、三（羟甲基）氨基甲烷[THAM]以及这些物质的组合）对人工胱氨酸结石的化学溶解作用。采用一种实验装置，通过计算机辅助在线测量数据，模拟不同pH值下上尿路的生理状况。
结果
与人工尿液和生理氯化钠溶液相比，所有溶液在胱氨酸结石溶解度方面均有统计学上的改善。THAM（pH 10）与2%乙酰半胱氨酸的组合效果最为显著（13.91±1.73毫克/小时），与人工尿液相比，溶解胱氨酸结石的能力高出41倍。
结论
我们的数据表明，使用特殊溶液进行局部化学溶解是胱氨酸结石治疗中的一种有效治疗方式。
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