Heimbach D, Jacobs D, Müller S C, Hesse A
Department of Urology, Division of Experimental Urology, University of Bonn, Germany.
Urol Int. 2002;69(3):212-8. doi: 10.1159/000063942.
This study was performed to look for an improvement of therapeutic strategies with regard to the treatment of infectious urinary stones using artificial stones made of struvite and apatite ('Bon(n) stones') which are comparable to their natural counterparts.
Using an experimental arrangement simulating the physiological conditions in the upper urinary tract, the efficacy of artificial urine (pH 5.7), Suby G solution (pH 3.6), mixtures of artificial urine with Suby G (pH 3.9 and pH 4.1) in dissolving artificial struvite and apatite stones (Bon(n) stones) was investigated. The dissolution of natural infectious urinary stones was also measured. Additionally, investigations on shock-wave lithotripsy (SWL) combined with initial chemolytic treatment of the stones were performed.
The efficacy of Suby G solution in dissolving artificial stones was demonstrated. Direct comparison of chemolysis of natural and artificial stones showed no statistical difference between infectious urinary stones and Bon(n) stones of the same material. The investigations on SWL showed a significant improvement on stone comminution, especially of artificial apatite stones after initial chemolytic treatment with Suby G.
New basics to improve dissolution of infectious urinary stones have been developed by performing standardized in vitro investigations. Local chemolysis with Suby G is an effective tool in the treatment of infectious stone disease. SWL can be improved by varying the physical properties of infectious stones through initial treatment with Suby G solution.
本研究旨在探寻针对感染性尿路结石治疗策略的改进方法，使用由鸟粪石和磷灰石制成的人工结石（“邦氏结石”），其与天然结石类似。
采用模拟上尿路生理状况的实验装置，研究人工尿液（pH 5.7）、苏比G溶液（pH 3.6）、人工尿液与苏比G的混合物（pH 3.9和pH 4.1）溶解人工鸟粪石和磷灰石结石（邦氏结石）的效果。同时测量天然感染性尿路结石的溶解情况。此外，还进行了冲击波碎石术（SWL）联合结石初始化学溶解治疗的研究。
证实了苏比G溶液溶解人工结石的效果。天然结石和人工结石化学溶解的直接比较显示，相同材料的感染性尿路结石和邦氏结石之间无统计学差异。SWL研究表明，在初始用苏比G进行化学溶解治疗后，结石粉碎情况有显著改善，尤其是人工磷灰石结石。
通过进行标准化的体外研究，已开发出改善感染性尿路结石溶解的新基础。用苏比G进行局部化学溶解是治疗感染性结石病的有效工具。通过先用苏比G溶液进行初始治疗来改变感染性结石的物理性质，可以改进SWL。
