Chong S A, Remington G J, Bezchlibnyk-Butler K Z
Schizophrenia Division, Clarke Institute of Psychiatry, Toronto, Canada.
Psychiatr Serv. 2000 Feb;51(2):250-2. doi: 10.1176/appi.ps.51.2.250.
Prescribing patterns for a group of outpatients with schizophrenia were surveyed for changes after the initiation of clozapine. Data were drawn from computerized pharmacy records, direct case record reviews, and interviews with the attending psychiatrists. The number of patients with two or more psychotropic drugs decreased by 31 percent after the initiation of clozapine, and a trend toward the use of clozapine without additional neuroleptics was detected. Decreases occurred in the use of anticholinergic agents, carbamazepine, and benzodiazepines, but selective serotonin reuptake inhibitors and sodium valproate were more likely to be prescribed concomitantly with clozapine.
对一组精神分裂症门诊患者在开始使用氯氮平后的处方模式变化进行了调查。数据来源于计算机化药房记录、直接病历审查以及对主治精神科医生的访谈。开始使用氯氮平后，使用两种或更多种精神药物的患者数量减少了31%，并且检测到一种不使用额外抗精神病药物而使用氯氮平的趋势。抗胆碱能药物、卡马西平和苯二氮䓬类药物的使用量减少，但选择性5-羟色胺再摄取抑制剂和丙戊酸钠更有可能与氯氮平联合使用。
