哺乳动物染色质结构域蛋白：它们在基因组组织与表达中的作用。

Mammalian chromodomain proteins: their role in genome organisation and expression.

作者信息

Jones D O, Cowell I G, Singh P B

机构信息

Nuclear Reprogramming Laboratory, Division of Integrative Biology, Roslin Institute (Edinburgh), Roslin, Midlothian, Scotland.

出版信息

Bioessays. 2000 Feb;22(2):124-37. doi: 10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E.

DOI:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E

PMID:10655032

Abstract

The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000.

摘要

染色质结构域是一种高度保守的序列基序，已在多种动植物物种中被鉴定出来。在哺乳动物中，染色质结构域蛋白似乎要么是大型大分子染色质复合物的结构成分，要么是参与重塑染色质结构的蛋白。最近的研究表明，除了在调节基因活性方面发挥作用外，染色质结构域蛋白在基因组组织中也可能发挥作用。本文综述了在鉴定哺乳动物染色质结构域蛋白方面取得的进展，并强调了它们在基因表达调控和基因组组织中日益凸显的作用。《生物论文》22:124 - 137，2000年。