ets蛋白PEA3可抑制HER-2/neu的过表达并抑制肿瘤发生。

The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis.

作者信息

Xing X, Wang S C, Xia W, Zou Y, Shao R, Kwong K Y, Yu Z, Zhang S, Miller S, Huang L, Hung M C

机构信息

The University of Texas M.D. Anderson Cancer Center, Department of Cancer Biology, Section of Molecular Cell Biology, Houston, Texas 77030, USA.

出版信息

Nat Med. 2000 Feb;6(2):189-95. doi: 10.1038/72294.

DOI:10.1038/72294

PMID:10655108

Abstract

Because HER-2/neu overexpression is important in cancer development, we looked for a method of suppressing the cell transformation mediated by HER-2/neu overexpression. We have identified that the DNA-binding protein PEA3, which is encoded by a previously isolated gene of the ets family, specifically targeted a DNA sequence on the HER-2/neu promoter and downregulated the promoter activity. Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu-overexpressing cancer cells. This is a new approach to targeting HER-2/neu overexpression and also provides a rationale to the design for repressors of diseases caused by overexpression of pathogenic genes.

摘要

由于HER-2/neu过表达在癌症发展中至关重要，我们寻找了一种抑制由HER-2/neu过表达介导的细胞转化的方法。我们已经确定，由ets家族先前分离的基因编码的DNA结合蛋白PEA3特异性靶向HER-2/neu启动子上的一个DNA序列，并下调启动子活性。PEA3的表达导致对HER-2/neu过表达癌细胞的细胞生长和肿瘤发展的优先抑制。这是一种针对HER-2/neu过表达的新方法，也为设计由致病基因过表达引起的疾病的抑制剂提供了理论依据。