Cancer Institute of The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute, Qingdao, China.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
J Exp Med. 2021 Jan 4;218(1). doi: 10.1084/jem.20201606.
Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy. Here, we summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism in cancer therapy.
脂质代谢失调是癌症中最显著的代谢改变之一。癌细胞利用脂质代谢来获取能量、生物膜的组成成分以及增殖、存活、侵袭、转移和对肿瘤微环境影响及癌症治疗反应所需的信号分子。在这里，我们总结和讨论了目前关于理解癌细胞中脂质代谢调控的进展，并介绍了临床上用于破坏癌症治疗中脂质代谢的不同方法。
