在猫鼻肉芽肿中产生菌丝成分的新型隐球菌温度敏感菌株。
Temperature-sensitive strain of Cryptococcus neoformans producing hyphal elements in a feline nasal granuloma.
作者信息
Bemis D A, Krahwinkel D J, Bowman L A, Mondon P, Kwon-Chung K J
机构信息
Department of Comparative Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA.
出版信息
J Clin Microbiol. 2000 Feb;38(2):926-8. doi: 10.1128/JCM.38.2.926-928.2000.
Abstract
We report the isolation of a temperature-sensitive, serotype A, mating type alpha strain of Cryptococcus neoformans from a case of nasal cryptococcosis in a cat. The strain grew extremely slowly at 35 degrees C and failed to grow at 37 degrees C in vitro. Histopathological sections of the infected tissue revealed yeast cells producing hyphae up to several hundred micrometers in length, in addition to numerous encapsulated yeast cells typical of C. neoformans. The cultures grown on yeast extract-peptone-glucose agar at 35 degrees C also produced some yeast cells with germ tube-like hyphal elements up to 100 microm in length.
摘要
我们报告了从一只患有鼻隐球菌病的猫身上分离出一株温度敏感型、血清A型、交配型α的新型隐球菌菌株。该菌株在35℃下生长极其缓慢，在37℃下体外无法生长。感染组织的组织病理学切片显示，除了大量典型的新型隐球菌包膜酵母细胞外，还有产生长达数百微米菌丝的酵母细胞。在35℃的酵母提取物-蛋白胨-葡萄糖琼脂上培养的菌株也产生了一些带有长达100微米的芽管样菌丝成分的酵母细胞。
相似文献
1
Temperature-sensitive strain of Cryptococcus neoformans producing hyphal elements in a feline nasal granuloma.在猫鼻肉芽肿中产生菌丝成分的新型隐球菌温度敏感菌株。
J Clin Microbiol. 2000 Feb;38(2):926-8. doi: 10.1128/JCM.38.2.926-928.2000.
2
Cryptococcus neoformans with a mutation in the tetratricopeptide repeat-containing gene, CCN1, causes subcutaneous lesions but fails to cause systemic infection.在含有四肽重复序列的基因CCN1中发生突变的新型隐球菌会导致皮下病变，但不会引起全身感染。
Infect Immun. 2003 Apr;71(4):1988-94. doi: 10.1128/IAI.71.4.1988-1994.2003.
3
Peripheral vestibular disease associated with cryptococcosis in three cats.三只猫中与隐球菌病相关的外周前庭疾病
J Feline Med Surg. 2000 Mar;2(1):29-34. doi: 10.1053/jfms.2000.0061.
4
Serotypes and mating types of clinical isolates from feline cryptococcosis in Japan.
J Vet Med Sci. 2006 Jan;68(1):91-4. doi: 10.1292/jvms.68.91.
5
Feline meningitis due to Cryptococcus neoformans var. neoformans and review of feline cryptococcosis.
Mycoses. 1991 Jul-Aug;34(7-8):313-6. doi: 10.1111/j.1439-0507.1991.tb00666.x.
6
Isolates of Cryptococcus neoformans from infected animals reveal genetic exchange in unisexual, alpha mating type populations.从受感染动物分离出的新型隐球菌菌株显示，在单性、α交配型群体中存在基因交换。
Eukaryot Cell. 2008 Oct;7(10):1771-80. doi: 10.1128/EC.00097-08. Epub 2008 Jun 13.
7
Asymptomatic carriage of Cryptococcus neoformans in the nasal cavity of dogs and cats.犬猫鼻腔中新隐球菌的无症状携带
J Med Vet Mycol. 1997 Jan-Feb;35(1):27-31.
8
PCR detection of the Cryptococcus neoformans CAPS9 gene from a biopsy specimen from a case of feline cryptococcosis.从一例猫隐球菌病病例的活检标本中进行新型隐球菌CAPS9基因的PCR检测。
J Vet Diagn Invest. 2001 Sep;13(5):439-42. doi: 10.1177/104063870101300516.
9
Cryptococcus neoformans granuloma in the lung and spinal cord of a free-ranging cheetah (Acinonyx jubatus). A clinical report and literature review.一只野生猎豹（猎豹属）肺部和脊髓中的新型隐球菌肉芽肿。临床报告及文献综述。
J S Afr Vet Assoc. 2005 Dec;76(4):228-32. doi: 10.4102/jsava.v76i4.432.
10
Cryptococcosis in cats: clinical and mycological assessment of 29 cases and evaluation of treatment using orally administered fluconazole.猫隐球菌病：29例临床和真菌学评估以及口服氟康唑治疗的疗效评价
J Med Vet Mycol. 1992;30(2):133-44. doi: 10.1080/02681219280000181.
引用本文的文献
1
Ocean warming and acidification have complex interactive effects on the dynamics of a marine fungal disease.海洋变暖与酸化对海洋真菌病的动态变化具有复杂的交互影响。
Proc Biol Sci. 2014 Jan 22;281(1778):20133069. doi: 10.1098/rspb.2013.3069. Print 2014 Mar 7.
2
Cryptococcosis in cats: ABCD guidelines on prevention and management.猫隐球菌病：预防与管理的ABCD指南
J Feline Med Surg. 2013 Jul;15(7):611-8. doi: 10.1177/1098612X13489224.
3
The link between morphotype transition and virulence in Cryptococcus neoformans.新型隐球菌形态转换与毒力的关系。
PLoS Pathog. 2012;8(6):e1002765. doi: 10.1371/journal.ppat.1002765. Epub 2012 Jun 21.
4
Profiling a killer, the development of Cryptococcus neoformans.剖析杀手，新型隐球菌的发展。
FEMS Microbiol Rev. 2012 Jan;36(1):78-94. doi: 10.1111/j.1574-6976.2011.00286.x. Epub 2011 Jul 4.
5
Transcription factors Mat2 and Znf2 operate cellular circuits orchestrating opposite- and same-sex mating in Cryptococcus neoformans.转录因子 Mat2 和 Znf2 运作细胞回路，在新型隐球菌中协调雌雄交配和同性交配。
PLoS Genet. 2010 May 13;6(5):e1000953. doi: 10.1371/journal.pgen.1000953.
6
A fungal granuloma of the frontal sinus in a llama.一只美洲驼额窦的真菌性肉芽肿。
Can Vet J. 2007 Sep;48(9):939-41.
7
Cryptococcus neoformans with a mutation in the tetratricopeptide repeat-containing gene, CCN1, causes subcutaneous lesions but fails to cause systemic infection.在含有四肽重复序列的基因CCN1中发生突变的新型隐球菌会导致皮下病变，但不会引起全身感染。
Infect Immun. 2003 Apr;71(4):1988-94. doi: 10.1128/IAI.71.4.1988-1994.2003.
8
Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans.交配型特异性和非特异性PAK激酶在新型隐球菌中发挥着共同和不同的作用。
Eukaryot Cell. 2002 Apr;1(2):257-72. doi: 10.1128/EC.1.2.257-272.2002.
9
Temperature-regulated transcription in the pathogenic fungus Cryptococcus neoformans.致病真菌新型隐球菌中的温度调节转录
Genome Res. 2002 Sep;12(9):1386-400. doi: 10.1101/gr.80202.
本文引用的文献
1
[AIDS-related cryptococcosis: diagnostic aspects, prognostic and therapeutic implications].
Ann Ital Med Int. 1998 Jan-Mar;13(1):8-12.
2
Cryptococcal infection in cats: factors influencing treatment outcome, and results of sequential serum antigen titers in 35 cats.猫隐球菌感染：影响治疗结果的因素及35只猫血清抗原滴度的连续检测结果
J Vet Intern Med. 1997 Jan-Feb;11(1):1-4. doi: 10.1111/j.1939-1676.1997.tb00064.x.
3
Cell-mediated immunity in HIV seronegative patients recovered from Cryptococcus neoformans var. gattii meningitis.从新型隐球菌格特变种脑膜炎中康复的HIV血清阴性患者的细胞介导免疫。
J Med Vet Mycol. 1997 Jan-Feb;35(1):7-11.
4
Evaluation of ketoconazole and itraconazole for treatment of disseminated cryptococcosis in cats.
Am J Vet Res. 1990 Sep;51(9):1454-8.
5
Cryptococcosis in cats: clinical and mycological assessment of 29 cases and evaluation of treatment using orally administered fluconazole.猫隐球菌病：29例临床和真菌学评估以及口服氟康唑治疗的疗效评价
J Med Vet Mycol. 1992;30(2):133-44. doi: 10.1080/02681219280000181.
Zotero 插件