Tsukamoto E, Itoh K, Katoh C, Mochizuki T, Shiga T, Morita K, Tamaki N
Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Ann Nucl Med. 1999 Dec;13(6):383-7. doi: 10.1007/BF03164931.
Renal uptake of 99mTc-DMSA has been quantified by various methods. The aim of this study is to obtain a normal value for 99mTc-DMSA renal uptake calculated by the posterior view method and age variation, and to assess its clinical validity. Scintigrams of 238 children (0-12 years) with 99mTc-DMSA were reviewed. All the children had a clinical history of primary vesicoureteral reflux and/or neurogenic bladder, ureteral or urethral anomalies. Their kidneys were divided into two groups, "normal" and "abnormal" according to their scintigraphic findings and split renal functions. Percent renal uptake per injected dose (% RU) was quantitated from planar images at 2 hours after injection of an age-adjusted dose (26-95 MBq) of 99mTc-DMSA. Calculated total % RU, individual % RU of the right and left kidneys (mean +/- sd) in patients with normal kidneys were 40.7 +/- 5.0%, 20.2 +/- 3.0%, 20.4 +/- 2.7%, respectively. There was no significant correlation between % RU and age (r = 0.231). Longitudinal variation in the % RU in 9 patients ranged from 1.2% to 18%. Our conventional method for quantifyng % RU is simple, practical and feasible in routine clinical practice, especially for children under follow up.
已通过多种方法对99mTc - DMSA的肾脏摄取进行了定量。本研究的目的是获得通过后位视图法计算的99mTc - DMSA肾脏摄取的正常值及其年龄变化，并评估其临床有效性。回顾了238例接受99mTc - DMSA检查的0至12岁儿童的闪烁扫描图。所有儿童均有原发性膀胱输尿管反流和/或神经源性膀胱、输尿管或尿道异常的临床病史。根据闪烁扫描结果和分肾功能，将他们的肾脏分为“正常”和“异常”两组。在注射经年龄调整剂量（26 - 95 MBq）的99mTc - DMSA后2小时，从平面图像定量每注射剂量的肾脏摄取百分比（% RU）。正常肾脏患者计算出的总% RU、右肾和左肾的个体% RU（平均值±标准差）分别为40.7±5.0%、20.2±3.0%、20.4±2.7%。% RU与年龄之间无显著相关性（r = 0.231）。9例患者的% RU纵向变化范围为1.2%至18%。我们用于定量% RU的传统方法在常规临床实践中简单、实用且可行，尤其适用于接受随访的儿童。
