角膜移植片中角膜小滴和富克斯角膜内皮营养不良的新生病变
Denovo development of corneal guttae and Fuchs' dystrophy in corneal grafts.
作者信息
Alexandrakis G, Filatov V, Adamis A P
机构信息
Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33136, USA.
出版信息
CLAO J. 2000 Jan;26(1):44-6.
PURPOSE
To describe two cases of de novo development of corneal guttae and Fuchs' dystrophy in donor tissue following penetrating keratoplasty (PK) for unrelated conditions.
METHODS
Two patients underwent PK for keratoconus and a disciform scar secondary to herpes simplex virus. They were followed clinically for a period of 16 and 11 years, respectively. Specular microscopy was used in one patient.
RESULTS
Corneal guttae were first noted 10 years and 4 years following transplantation in the first and second patient, respectively. In both cases, the corneal guttae gradually increased in number, involving the central and temporal portions of the corneal graft There were no corneal guttae present in the host corneal rim or contralateral cornea of either patient.
CONCLUSIONS
These cases provide evidence to suggest that some corneas may be genetically predetermined to develop corneal guttae and Fuchs' dystrophy many years before any changes can be clinically detected.
目的
描述两例因无关病症接受穿透性角膜移植术（PK）后供体组织中新生角膜小滴和Fuchs角膜内皮营养不良的病例。
方法
两名患者分别因圆锥角膜和单纯疱疹病毒继发的盘状瘢痕接受了PK。他们分别接受了16年和11年的临床随访。其中一名患者使用了镜面显微镜检查。
结果
第一例和第二例患者分别在移植后10年和4年首次发现角膜小滴。在这两例中，角膜小滴数量逐渐增加，累及角膜移植片的中央和颞侧部分。两名患者的宿主角膜边缘或对侧角膜均未出现角膜小滴。
结论
这些病例提供了证据，表明一些角膜可能在临床检测到任何变化之前许多年就已在基因上预先注定会发展为角膜小滴和Fuchs角膜内皮营养不良。
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