Padhani A R, Gapinski C J, Macvicar D A, Parker G J, Suckling J, Revell P B, Leach M O, Dearnaley D P, Husband J E
Academic Department of Radiology, Institute of Cancer Research, The Royal Marsden NHS Trust, Downs Road, Sutton, Surrey, SM2 5PT, U.K.
Clin Radiol. 2000 Feb;55(2):99-109. doi: 10.1053/crad.1999.0327.
To quantify MRI enhancement characteristics of normal and abnormal prostatic tissues and to correlate these with tumour stage, histological grade and tumour markers.
Quantitative gradient recalled echo MR images were obtained following bolus injection of gadopentetate dimeglumine in 48 patients with prostate cancer. Turbo spin-echo T2-weighted images at the same anatomical position were reviewed for the presence of tumours (45 regions), normal peripheral zone (33 regions), and normal appearing central gland (30 regions). Time-signal intensity parameters (onset time, mean gradient and maximal amplitude of enhancement and wash-out score) and modelling parameters (permeability surface area product, lesion leakage space and maximum gadolinium concentration) were correlated with tumour stage, histological grade (Gleason score) and serum prostatic specific antigen (PSA) levels.
Significant differences were noted between peripheral zone and tumour with respect to signal intensity and modelling parameters (P = 0.0001), except onset time. No differences between central gland and tumour enhancement values were seen. There was weak correlation between MRI tumour stage and tumour vascular permeability (r(2) = 12%; P = 0.02) and maximum tumour gadolinium concentration (r(2) = 14%; P = 0.015). However, no significant correlations were seen with Gleason score or PSA levels.
Quantification of MR contrast enhancement characteristics allows tissue discrimination in prostate cancer consistent with known variations in microvessel density estimates.
量化正常和异常前列腺组织的MRI增强特征，并将这些特征与肿瘤分期、组织学分级和肿瘤标志物相关联。
对48例前列腺癌患者静脉注射钆喷酸葡胺后获取定量梯度回波MR图像。回顾同一解剖位置的快速自旋回波T2加权图像，观察肿瘤（45个区域）、正常外周带（33个区域）和外观正常的中央腺体（30个区域）的情况。将时间-信号强度参数（起始时间、平均梯度、增强的最大幅度和廓清分数）和建模参数（通透表面积乘积、病变渗漏空间和最大钆浓度）与肿瘤分期、组织学分级（Gleason评分）和血清前列腺特异性抗原（PSA）水平相关联。
除起始时间外，外周带和肿瘤在信号强度和建模参数方面存在显著差异（P = 0.0001）。中央腺体和肿瘤增强值之间未见差异。MRI肿瘤分期与肿瘤血管通透性（r(2) = 12%；P = 0.02）和最大肿瘤钆浓度（r(2) = 14%；P = 0.015）之间存在弱相关性。然而，与Gleason评分或PSA水平未见显著相关性。
MR对比增强特征的量化能够在前列腺癌中实现组织鉴别，这与微血管密度估计的已知差异相符。
