van den Buuse M, Head G A
Neuropharmacology Laboratory, Baker Medical Research Institute, Commercial Road, Prahran, Melbourne, Australia.
Eur J Pharmacol. 2000 Jan 24;388(1):85-8. doi: 10.1016/s0014-2999(99)00835-3.
Intravenous administration of 0.3 mg/kg of quinpirole to conscious rabbits that had been pretreated with domperidone caused a marked increase in blood pressure and renal sympathetic nerve activity with a peak at 5-10 min after injection (25% and 3-fold increase, respectively). Spectral analysis of the blood pressure-renal sympathetic nerve activity relationship in the 0.2-0.4 Hz domain showed that baroreflex gain was markedly increased at 5-10 min (4-fold) and at 20-25 min after injection (3.7-fold). These results show that administration of the dopamine D(2)/D(3) receptor agonist quinpirole causes profound and long-lasting changes in the central integration of the sympathetic baroreceptor-vasomotor reflex.
对已用多潘立酮预处理的清醒家兔静脉注射0.3 mg/kg喹吡罗，可使血压和肾交感神经活动显著增加，注射后5 - 10分钟达到峰值（分别增加25%和3倍）。在0.2 - 0.4 Hz域对血压 - 肾交感神经活动关系进行频谱分析表明，注射后5 - 10分钟（4倍）和20 - 25分钟（3.7倍）压力感受性反射增益显著增加。这些结果表明，多巴胺D(2)/D(3)受体激动剂喹吡罗的给药会引起交感压力感受器 - 血管运动反射中枢整合的深刻而持久的变化。
