Schwarz M A, Firkin B G
Med J Aust. 1976 May 8;1(19):687-90.
The effect of chloramphenicol in short term in-vitro bone marrow cultures was studied. There was a striking reduction in the incorporation of tritiated thymidine into DNA in bone marrow cultures with abnormal proliferative properties as compared with normal tissue. A 50% reduction in DNA thymidine incorporation in leukaemia marrow was also obtained with in-vitro chloramphenicol concentrations which in contrast had little or no effect in normal tissue. These in-vitro levels of the antibiotic can be readily achieved in vivo. An in-vivo study confirmed the ability of chloramphenicol to reduce the white cell and blast count in a patient with chronic myeloid leukaemia in blastic transformation.
研究了氯霉素在短期体外骨髓培养中的作用。与正常组织相比，具有异常增殖特性的骨髓培养物中，氚标记胸腺嘧啶核苷掺入DNA的量显著减少。体外氯霉素浓度也能使白血病骨髓中的DNA胸腺嘧啶核苷掺入量减少50%，相比之下，该浓度对正常组织几乎没有影响。抗生素的这些体外浓度在体内很容易达到。一项体内研究证实，氯霉素能够降低一名处于原始细胞转化期的慢性髓性白血病患者的白细胞和原始细胞计数。
