Ohnishi H, Kamimura T, Gondo H, Okamura T, Niho Y, Yao T
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.
Rinsho Ketsueki. 1999 Dec;40(12):1265-70.
We encountered a 65-year-old woman with diffuse large B-cell lymphoma showing t(8;14)(q24;q32) and c-myc gene rearrangement that developed following 12 years of melphalan-based chemotherapy for multiple myeloma. Short-term remission was obtained by CHOP chemotherapy. However, shortly thereafter the patient died of an aggressive progression of lymphoma. It was suspected that the lymphoma was a secondary malignancy related to the treatment with cytotoxic agents and radiation for prolonged multiple myeloma. The chromosomal abnormality t(8;14)(q24;q32) is rare in secondary malignancies. Overexpression of c-myc by gene rearrangement may be associated with clinical courses manifested by the rapid progression of lymphoma.
我们遇到一名65岁女性，患有弥漫性大B细胞淋巴瘤，具有t(8;14)(q24;q32)和c-myc基因重排，该淋巴瘤在针对多发性骨髓瘤进行了12年的美法仑化疗后发生。通过CHOP化疗获得了短期缓解。然而，此后不久患者死于淋巴瘤的侵袭性进展。怀疑该淋巴瘤是与长期多发性骨髓瘤的细胞毒性药物治疗和放疗相关的继发性恶性肿瘤。染色体异常t(8;14)(q24;q32)在继发性恶性肿瘤中罕见。基因重排导致的c-myc过表达可能与淋巴瘤快速进展所表现的临床病程相关。
