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孟加拉国一例复发的BT型麻风病例,经4.5年不规则治疗后出现广泛皮肤损害,组织病理学显示为未定类。

A recurrent case of BT leprosy with widely spread skin lesions showing a histopathology of indeterminate group after 4.5-years irregular treatment, Bangladesh.

作者信息

Ishida Y, Ozaki M, Picorini L, Guglielmelli E

机构信息

PIME Sisters Khulna Leprosy Program, Boro Boyra, Khulna, Bangladesh.

出版信息

Nihon Hansenbyo Gakkai Zasshi. 1999 Nov;68(3):195-9. doi: 10.5025/hansen.68.195.

Abstract

A 29 year-old Bengali male case is presented in this paper which was a borderline tuberculoid leprosy (BT) at detection. His father contracted a lepromatous leprosy of G = 2 deformity. He took anti-leprosy drugs including MDT/MB regimen irregularly and had maculae widely-spread with anesthesia 16 months after being released from treatment (RFT). The histopathology of the maculae unexpectedly showed that of an indeterminate group of leprosy. The recurrent skin lesions were susceptive to a four-week regimen of Rifampicin and Ofloxacin. This case can not be defined as a relapsed case, because slit skin smears were always negative. It would be called a recurrent case after MDT/MB regimen. Though the reason recurrent skin lesions occur is unknown, it is reasonable to assume that the recurrent lesions are caused by dormant persisters which are originally drug sensitive. The recurrent skin lesions can not be classified because the clinical features can not be matched to their histology. Such recurrent cases might occur among the defaulters of MDT in future.

摘要

本文介绍了一例29岁的孟加拉男性病例,该病例在确诊时为边缘结核样型麻风(BT)。他的父亲患瘤型麻风,残疾等级为2级。他曾不规则服用包括多药联合化疗/少菌型方案(MDT/MB)在内的抗麻风药物,停药后16个月出现广泛分布的带有麻木感的斑疹。斑疹的组织病理学检查结果出人意料地显示为未定类麻风。复发性皮肤损害对利福平与氧氟沙星的四周治疗方案敏感。该病例不能被定义为复发病例,因为皮肤涂片检查始终为阴性。在接受MDT/MB方案治疗后,应称其为复发病例。虽然复发性皮肤损害发生的原因尚不清楚,但推测复发损害是由原本对药物敏感的持留菌引起的,这是合理的。由于临床特征与组织学表现不匹配,复发性皮肤损害无法分类。未来,此类复发病例可能会在MDT治疗的失访者中出现。

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