In 1993 the International Medical Informatics Association approved a working group whose purpose focused on the people and organizational issues surrounding the use of computers in health care. This article outlines two key concepts that act as the guiding principles for the working group's efforts. The concepts are: applying the knowledge of human behaviors toward the use of information or information technology within a health care environment and effectively incorporating human factors, culture, change, and organizational and human engineering in the medical informatics processes. These concepts are further supported by functional statements and a strategy to ensure the principles are effectively diffused in the medical informatics community. The concepts, functional statements and process were adopted by the working group and are outlined in this article.