Steciuk M, Kram M, Kramer G L, Petty F
North Texas Veterans Affairs Medical Center, Dallas 75216, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jan;24(1):155-61. doi: 10.1016/s0278-5846(99)00078-0.
Previous research suggests that 5-HT1A receptors are altered with exposure to chronic stress. No previous studies have examined the effect of acute stress on 5-HT1A. Using receptor autoradiography it was observed that there were no differences in [3H]-8-OH-DPAT binding between control rats and rats that received 20 minutes of restraint stress 2 hours prior to sacrifice. This study suggests that the changes in 5-HT1A receptor density associated with chronic stress develop over the course of repeated stress.
先前的研究表明，5-羟色胺1A受体（5-HT1A）会因长期暴露于应激状态而发生改变。此前尚无研究探讨急性应激对5-HT1A的影响。通过受体放射自显影法观察到，对照组大鼠与在处死前2小时接受20分钟束缚应激的大鼠之间，[3H]-8-羟基二丙胺基四氢萘（[3H]-8-OH-DPAT）结合并无差异。本研究表明，与慢性应激相关的5-HT1A受体密度变化是在反复应激过程中逐渐形成的。
