Ismail I S, Nazaimoon W M, Mohamad W B, Letchuman R, Singaraveloo M, Pendek R, Faridah I, Rasat R, Sheriff I H, Khalid B A
Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Diabetes Res Clin Pract. 2000 Jan;47(1):57-69. doi: 10.1016/s0168-8227(99)00104-7.
Recent studies have shown that good glycaemic control can prevent the development of diabetic complications in type 1 and type 2 diabetes. We wished to observe the glycaemic control in patients from different centres in Peninsular Malaysia and the factors that determine it. We recruited 926 patients with diabetes diagnosed before age 40 years from seven different centres, with proportionate representation from the three main ethnic groups. Clinical history and physical examination were done and blood taken for HbA1c and fasting glucose. The overall glycaemic control was poor with geometric mean HbA1c of 8.6% whilst 61.1% of the patients had HbA1c greater than 8%. Glycaemic control in patients with type 2 diabetes varied between various centres and ethnic groups, with the best control obtained in Chinese patients. Significant predictors of HbA1c in both type 1 and type 2 diabetes include access to nurse educators, ethnic background and WHR. In type 2 diabetes, use of insulin was a significant predictor, while in type 1 diabetes, household income was a significant predictor. Socioeconomic status did not have a significant effect in type 2 diabetes. There were no significant differences in the glycaemic control in patients with different educational status. In conclusion, glycaemic control in big hospitals in Malaysia was poor, and was closely related to the availability of diabetes care facilities and ethnic group, rather than socioeconomic status.
近期研究表明,良好的血糖控制可预防1型和2型糖尿病患者发生糖尿病并发症。我们希望观察马来西亚半岛不同中心患者的血糖控制情况及其影响因素。我们从7个不同中心招募了926例40岁前确诊的糖尿病患者,三大主要种族均有相应比例的代表。记录临床病史并进行体格检查,采集血液检测糖化血红蛋白(HbA1c)和空腹血糖。总体血糖控制较差,糖化血红蛋白几何平均值为8.6%,61.1%的患者糖化血红蛋白大于8%。2型糖尿病患者的血糖控制在不同中心和种族之间存在差异,华裔患者的血糖控制最佳。1型和2型糖尿病患者糖化血红蛋白的显著预测因素包括是否有护士教育人员、种族背景和腰臀比(WHR)。在2型糖尿病中,使用胰岛素是一个显著的预测因素,而在1型糖尿病中,家庭收入是一个显著的预测因素。社会经济地位对2型糖尿病患者没有显著影响。不同教育程度患者的血糖控制没有显著差异。总之,马来西亚大医院的血糖控制较差,且与糖尿病护理设施的可及性和种族密切相关,而非社会经济地位。