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Leukapheresis by continuous flow centrifugation (CFC) in patients with chronic myelocytic leukemia (CML).慢性粒细胞白血病（CML）患者通过连续流动离心法（CFC）进行白细胞分离术。
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2
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Cancer Res. 1972 Jun;32(6):1307-14.
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Letter: DNA-daunorubicin complex: preliminary trials in human leukaemia.信函：DNA-柔红霉素复合物：人类白血病的初步试验
Eur J Cancer (1965). 1973 May;9(5):391-2. doi: 10.1016/0014-2964(73)90058-3.
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Factors influencing microculture in leukaemia cells.影响白血病细胞微培养的因素。
Nature. 1974 Oct 25;251(5477):741-2. doi: 10.1038/251741a0.
5
Management of adult acute myelogenous leukaemia.成人急性髓细胞白血病的管理
Br Med J. 1973 Jan 20;1(5846):131-7. doi: 10.1136/bmj.1.5846.131.
6
Acute leukemia in adults.成人急性白血病
Semin Hematol. 1974 Jan;11(1):5-24.
7
Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia.成人急性白血病外周血培养特征的诊断及预后意义
Br J Cancer. 1976 Apr;33(4):400-10. doi: 10.1038/bjc.1976.65.

一名急性髓性白血病患者对柔红霉素产生获得性耐药。

Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia.

作者信息

Smith B J, Kundu D

出版信息

Br J Cancer. 1976 Jul;34(1):53-7. doi: 10.1038/bjc.1976.121.

DOI:10.1038/bjc.1976.121
PMID:1066148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2025136/
Abstract

Measurement of in vitro and in vivo resistance to daunorubicin in AML patients suggests that there is no simple correlation between the two. In a patient who became clinically resistant and whose cells showed a parallel increased resistance in vitro we found the acquisition of multiple drug resistance. The increased in vitro resistance to daunorubicin could to some extent be overcome by conjugating daunorubicin to DNA.

摘要

对急性髓系白血病（AML）患者体外和体内对柔红霉素耐药性的测量表明，二者之间不存在简单的相关性。在一名临床上出现耐药且其细胞在体外显示出平行增加的耐药性的患者中，我们发现了多药耐药性的获得。通过将柔红霉素与DNA结合，体外对柔红霉素增加的耐药性在一定程度上可以被克服。