Pique C, Ureta-Vidal A, Gessain A, Chancerel B, Gout O, Tamouza R, Agis F, Dokhélar M C
Institut National de la Santé et de la Recherche Médicale, U332, Institut Cochin de Génétique Moléculaire, 75014 Paris, France.
J Exp Med. 2000 Feb 7;191(3):567-72. doi: 10.1084/jem.191.3.567.
Human T cell leukemia virus type I (HTLV-I) is a persistent virus that causes adult T cell leukemia and tropical spastic paraparesis/HTLV-I-associated myelopathy. Studies on rabbits have shown that viral proteins encoded by the open reading frames pX-I and pX-II are required for the establishment of the persistent infection. To examine the in vivo production of these proteins in humans, we have investigated whether cytotoxic T lymphocytes isolated from HTLV-I-infected individuals recognized pX-I and pX-II peptides. CD8(+) T lymphocytes to pX-I and pX-II peptides were detected in HTLV-I-infected individuals, whatever their clinical status, and even in the absence of any antigenic restimulation. These findings indicate that the HTLV-I pX-I and pX-II proteins are chronically synthesized in vivo, and are targets of the natural immune response to the virus.
人类嗜T淋巴细胞病毒I型（HTLV-I）是一种持续性病毒，可导致成人T细胞白血病和热带痉挛性截瘫/HTLV-I相关脊髓病。对兔子的研究表明，由开放阅读框pX-I和pX-II编码的病毒蛋白是建立持续性感染所必需的。为了检测这些蛋白在人体内的体内产生情况，我们研究了从HTLV-I感染个体中分离出的细胞毒性T淋巴细胞是否识别pX-I和pX-II肽段。无论HTLV-I感染个体的临床状态如何，甚至在没有任何抗原再刺激的情况下，均可检测到针对pX-I和pX-II肽段的CD8(+) T淋巴细胞。这些发现表明，HTLV-I的pX-I和pX-II蛋白在体内持续合成，并且是针对该病毒的天然免疫反应的靶点。
