Jivraj I, Martini LG, Thomson CM
The London School of Pharmacy, University of London, Brunswick Square, London, UK WC1N 1AX.
Pharm Sci Technol Today. 2000 Feb;3(2):58-63. doi: 10.1016/s1461-5347(99)00237-0.
The humble tablet dosage form still accounts for more than 80% of all dosage forms administered to man. This review will outline the various excipients that have been used as fillers in direct compression formulations, with particular emphasis on what is expected from such excipients in terms of their functionality. It is intended that this overview (which is by no means exhaustive) will serve as an 'aide-memoire' to the formulation scientist.
普通的片剂剂型在给人类使用的所有剂型中仍占80%以上。本综述将概述在直接压片制剂中用作填充剂的各种辅料,特别强调此类辅料在功能方面的预期要求。本概述(绝非详尽无遗)旨在为制剂科学家提供一份“备忘录”。