Franc Aleš, Vetchý David, Vodáčková Pavlína, Kubaľák Roman, Jendryková Lenka, Goněc Roman
Ceska Slov Farm. 2018 Dec 18;67(5-6):175-181.
Tablets are the most frequently employed dosage form. Their advantage lies in their availability, easy administration, good stability, and low price. The easiest technology to produce tablets is direct compression, even though the use of the method requires overcoming many obstacles, mainly related to content uniformity and variation of mass, disintegration, dissolution, and radial hardness of tablets. “Co-processed excipients”, containing commonly processed blends of fillers, binders, disintegrants, lubricants, and other excipients are more and more widely used nowadays. These mixtures are manufactured by various technologies, chiefly by spray-drying, fluid bed granulation, wet granulation, melt granulation, dry granulation, and co-crystallisation. This review article lists excipients used usually to constitute co-processed excipients, technologies, and commercially available co-processed excipients for direct compression.
片剂是最常用的剂型。它们的优点在于其可得性、易于给药、稳定性好且价格低廉。生产片剂最简单的技术是直接压片，尽管使用该方法需要克服许多障碍，主要涉及含量均匀度、片重差异、崩解、溶出以及片剂的径向硬度。如今，含有常用填充剂、粘合剂、崩解剂、润滑剂和其他辅料加工混合物的“共处理辅料”越来越广泛地被使用。这些混合物通过各种技术制造，主要是喷雾干燥、流化床制粒、湿法制粒、熔融制粒、干法制粒和共结晶。这篇综述文章列出了通常用于构成直接压片共处理辅料的辅料、技术以及市售的共处理辅料。
