[心脏直视手术后血清脑钠肽（BNP）水平是否反映心肌保护作用？]

[Dose the serum brain natriuretic peptide (BNP) level after open heart surgery reflect myocardial protection?].

作者信息

Shirasawa B, Hamano K, Kawamura T, Gohra H, Katoh T, Fujimura Y, Zempo N, Esato K

机构信息

First Department of Surgery, Yamaguchi University School of Medicine, Ube, Japan.

出版信息

Kyobu Geka. 2000 Feb;53(2):123-6.

PMID:10667022

Abstract

This clinical study was conducted to determine whether the serum BNP level after open heart surgery reflects myocardial protection. The levels of BNP and CPK-MB were measured before and after 12 hours of cardiopulmonary bypass, then 1, 3, and 6 days after open heart surgery, and the relationship between the maximum levels of BNP and the CPK-MB after open heart surgery was examined. The patients were divided into two groups according to whether or not the maximum CPK MB was more than 100 IU/l after open heart surgery. A significant relationship between the maximum BNP and the maximum CPK-MB after open heart surgery was observed (p = 0.013). Moreover, the BNP was significantly increased in the group of patients with a maximum CPK-MB > or = 100 IU/l, compared to that in those with a maximum CPK-MB < 100 IU/l, 12 hours 1 day, and 6 days after open heart surgery (p < 0.01). These findings indicate that the serum level of BNP after open heart surgery can reflect myocardial protection.

摘要

本临床研究旨在确定心脏直视手术后血清脑钠肽（BNP）水平是否反映心肌保护情况。在体外循环12小时前后、心脏直视手术后1天、3天和6天测量BNP和肌酸磷酸激酶同工酶（CPK-MB）水平，并检测心脏直视手术后BNP最高水平与CPK-MB最高水平之间的关系。根据心脏直视手术后CPK-MB最高值是否超过100 IU/l将患者分为两组。观察到心脏直视手术后BNP最高水平与CPK-MB最高水平之间存在显著相关性（p = 0.013）。此外，与CPK-MB最高值<100 IU/l的患者相比，CPK-MB最高值≥100 IU/l的患者组在心脏直视手术后12小时、1天和6天的BNP显著升高（p < 0.01）。这些结果表明，心脏直视手术后血清BNP水平可反映心肌保护情况。