Devchand P R, Ijpenberg A, Devesvergne B, Wahli W
Institut de Biologie Animale, Université de Lausanne, Switzerland.
Adv Exp Med Biol. 1999;469:231-6. doi: 10.1007/978-1-4615-4793-8_34.
The peroxisome proliferator-activated receptors have enjoyed the spotlight for many reasons. These transcription factors are ligand-inducible nuclear receptors that modulate gene expression in response to a broad spectrum of compounds. The recognition that PPARs are indeed nuclear receptors for polyunsaturated fatty acids, some eicosanoids and also lipid-lowering and antidiabetic drugs, has opened many exciting avenues of research and drug discovery. Recent studies on the PPAR function have extended the role of these transcription factors beyond energy homeostasis to master gene in adipogenesis and also determinants in inflammation control. While rapid advances have been made, it is clear that we are far from a global understanding of the mechanisms and functions of PPARs.
过氧化物酶体增殖物激活受体（PPARs）因多种原因备受关注。这些转录因子是配体诱导型核受体，可响应多种化合物调节基因表达。认识到PPARs实际上是多不饱和脂肪酸、某些类二十烷酸以及降脂和抗糖尿病药物的核受体，开辟了许多令人兴奋的研究和药物发现途径。最近关于PPAR功能的研究已将这些转录因子的作用从能量稳态扩展到脂肪生成中的主控基因以及炎症控制的决定因素。尽管已取得快速进展，但显然我们对PPARs的机制和功能仍远未全面了解。
