Fan Y Y, Ramos K S, Chapkin R S
Faculty of Nutrition, Texas A&M University, College Station 77843, USA.
Adv Exp Med Biol. 1999;469:485-91. doi: 10.1007/978-1-4615-4793-8_71.
Data from our in vitro studies indicate that macrophages isolated from mice fed GLA-enriched diets inhibit vascular SMC proliferation via a PGE1-cAMP dependent mechanism. Since SMC proliferation is one of the main events implicated in the pathogenesis of atherosclerosis (Ross, 1993), this anti-proliferative effect observed by dietary GLA is noteworthy. In vivo studies have established that dietary GLA is capable of retarding the atherosclerotic lesion formation in ApoE knock out mice, an animal model that develops atherosclerosis similar to humans (Reddick, 1994). We propose that dietary GLA has the potential to inhibit SMC proliferation leading to retardation of atherosclerotic lesion formation, and therefore favorable modulation of the atherogenic process.
我们的体外研究数据表明，从喂食富含γ-亚麻酸（GLA）饮食的小鼠中分离出的巨噬细胞，通过一种前列腺素E1-环磷酸腺苷（PGE1-cAMP）依赖机制抑制血管平滑肌细胞（SMC）增殖。由于平滑肌细胞增殖是动脉粥样硬化发病机制中的主要事件之一（罗斯，1993年），因此膳食γ-亚麻酸所观察到的这种抗增殖作用值得关注。体内研究已经证实，膳食γ-亚麻酸能够延缓载脂蛋白E基因敲除小鼠的动脉粥样硬化病变形成，这是一种与人类动脉粥样硬化发展相似的动物模型（雷迪克，1994年）。我们认为，膳食γ-亚麻酸有可能抑制平滑肌细胞增殖，从而延缓动脉粥样硬化病变形成，进而对动脉粥样硬化进程产生有利调节作用。
