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Central role of arachidonate 5-lipoxygenase in the regulation of cell growth and apoptosis in human prostate cancer cells.

作者信息

Ghosh J, Myers C E

机构信息

University of Virginia Cancer Center, Charlottesville 22908, USA.

出版信息

Adv Exp Med Biol. 1999;469:577-82. doi: 10.1007/978-1-4615-4793-8_84.

DOI:10.1007/978-1-4615-4793-8_84
PMID:10667385
Abstract
摘要

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Central role of arachidonate 5-lipoxygenase in the regulation of cell growth and apoptosis in human prostate cancer cells.花生四烯酸5-脂氧合酶在人前列腺癌细胞生长和凋亡调控中的核心作用。
Adv Exp Med Biol. 1999;469:577-82. doi: 10.1007/978-1-4615-4793-8_84.
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Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer cells.抑制5-脂氧合酶可选择性地引发前列腺癌细胞中c-Myc信号传导的破坏。
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Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase.花生四烯酸5-脂氧合酶的抑制通过c-Jun氨基末端激酶的快速激活触发前列腺癌细胞死亡。
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Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells.花生四烯酸5-脂氧合酶的抑制触发人前列腺癌细胞的大量凋亡。
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Fatty acid release and oxidation are factors in lipoxygenase inhibitor-induced apoptosis.脂肪酸释放和氧化是脂氧合酶抑制剂诱导细胞凋亡的因素。
Toxicol Lett. 2003 Mar 3;138(3):193-203. doi: 10.1016/s0378-4274(02)00407-1.

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