Ghaziuddin N, King C A, Hovey J D, Zaccagnini J, Ghaziuddin M
University of Michigan, Ann Arbor, USA.
Child Psychiatry Hum Dev. 1999 Winter;30(2):103-10. doi: 10.1023/a:1021950301932.
The purpose of the study was to estimate prevalence of medication noncompliance among adolescents, following discharge from hospital. A second purpose was to identify predictors of such noncompliance. Seventy-one adolescents, who had been prescribed a medication during psychiatric hospitalization, were interviewed by telephone, 6-8 months post-hospitalization. Medication noncompliance was defined as discontinuing medication without the recommendation of the treating physician. Twenty-four subjects (33.8%) were noncompliant with medication. Age, race, gender, SES, diagnosis, type and number of medications, severity of depression, and family living arrangement did not predict noncompliance. We concluded that noncompliance with psychotropic medications was relatively common and difficult to predict in adolescents who had been hospitalized to a psychiatric inpatient unit; the majority of them suffered from depression. Clinicians should be aware that medication noncompliance may be common and a relatively unpredictable phenomenon.
该研究的目的是评估青少年出院后药物治疗不依从的发生率。另一个目的是确定这种不依从的预测因素。71名在精神科住院期间曾被开了药物的青少年，在出院后6至8个月接受了电话访谈。药物治疗不依从被定义为在没有主治医生建议的情况下停药。24名受试者（33.8%）存在药物治疗不依从情况。年龄、种族、性别、社会经济地位、诊断、药物类型和数量、抑郁严重程度以及家庭居住安排均不能预测不依从情况。我们得出结论，在入住精神科住院部的青少年中，精神药物治疗不依从情况相对常见且难以预测；他们中的大多数患有抑郁症。临床医生应意识到，药物治疗不依从可能很常见且是一种相对不可预测的现象。
