Rodiño S, Rama P, Pensado A, Dávila M L, Molins N, Fraga M
Servicio de Anestesia y Reanimación, Complexo Hospitalario Juan Canalejo, A Coruña.
Rev Esp Anestesiol Reanim. 1999 Dec;46(10):427-32.
To compare the recovery of patients after anesthesia with sevoflurane or propofol during open urological surgery or lumbar column surgery of intermediate duration.
Thirty-six ASA I, II or II patients were enrolled prospectively and randomly assigned to two groups to receive either sevoflurane (n = 19) or proporol (n = 17). Anesthetic induction was accomplished with thiopental, fentanil and vecuronium. During anesthetic maintenance a mixture of 60% nitrous oxide in oxygen plus the drug under study was adjusted to keep blood pressure and/or heart rate within +/- 20% of baseline. After surgery we recorded time until eye opening, spontaneous breathing, extubation, orientation, and identification of parts of the body. Side effects were likewise recorded. In the postanesthetic recovery ward patient condition was assessed using the Aldrete scale, the Newman-Trieger test and a visual analog scale for postoperative pain. Consumption of analgesic during the first 24 h after surgery was monitored.
No significant differences were found in demographic data; duration of anesthesia; anesthetic doses; or time until spontaneous breathing, extubation, orientation or identification of parts of the body. Only time until eye opening was shorter in the sevoflurane group than in the propofol group (6.9 +/- 3.3 vs 11.5 +/- 4.8 min; p < 0.05). No differences were recorded on scales reflecting intermediate-term recovery. Analgesic consumption and the incidence of side effects were similar in both groups.
Sevoflurane and propofol are comparable for anesthetic maintenance in urological and neurological procedures of intermediate duration.
比较在泌尿外科开放手术或中等时长的腰椎手术中，使用七氟醚或丙泊酚麻醉后患者的恢复情况。
前瞻性纳入36例美国麻醉医师协会（ASA）分级为I、II或III级的患者，并随机分为两组，分别接受七氟醚（n = 19）或丙泊酚（n = 17）麻醉。麻醉诱导采用硫喷妥钠、芬太尼和维库溴铵。麻醉维持期间，调整含60%氧化亚氮的氧气与研究药物的混合气体，使血压和/或心率维持在基线值的±20%以内。术后记录睁眼时间、自主呼吸恢复时间、拔管时间、定向力恢复时间以及身体部位识别时间。同时记录副作用情况。在麻醉后恢复病房，使用Aldrete评分、Newman-Trieger试验和术后疼痛视觉模拟评分评估患者状况。监测术后24小时内的镇痛药消耗量。
在人口统计学数据、麻醉时长、麻醉剂量、自主呼吸恢复时间、拔管时间、定向力恢复时间或身体部位识别时间方面，未发现显著差异。仅七氟醚组的睁眼时间短于丙泊酚组（6.9 ± 3.3 vs 11.5 ± 4.8分钟；p < 0.05）。在反映中期恢复的评分上未记录到差异。两组的镇痛药消耗量和副作用发生率相似。
在中等时长的泌尿外科和神经外科手术中，七氟醚和丙泊酚用于麻醉维持的效果相当。
