Yeşildağ O, Yazici M, Yilmaz O, Uçar R, Sağkan O
University of Ondokuz Mayis, Faculty of Medicine, Dept. of Cardiology, Samsun, Turkey.
Acta Cardiol. 1999 Dec;54(6):335-7.
Aminophylline was known to decrease effort angina and ischaemia in patients with coronary artery disease and stable angina. This effect has been explained by the antagonization of the vasodilatation caused by adenosine and the prevention of the transmural myocardial maldistribution (steal phenomenon). In this study, treadmill exercise tests (with Bruce protocol) were performed in 14 patients (11 women, 3 men, mean age 51 +/- 9.9 years) diagnosed with syndrome X (typical anginal chest pain, abnormal stress test, normal coronary angiography) before (basal condition) and after the acute i.v. aminophylline infusion (total dosage 6 mg/kg within 15 minutes). It was shown that aminophylline lengthened the time before the occurrence of ischaemia in patients with syndrome X by increasing the ischaemia threshold in spite of the occurrence of tachycardia but it had no effect on the total exercise duration. Aminophylline infusion also exerted a beneficial effect on exercise-induced chest pain. It has been suggested that the role of the adenosine receptor could be important in the pathogenesis of syndrome X.
已知氨茶碱可减轻冠状动脉疾病和稳定型心绞痛患者的劳力性心绞痛及缺血症状。这种作用被解释为对腺苷引起的血管舒张的拮抗作用以及对跨壁心肌分布不均（窃血现象）的预防。在本研究中，对14例被诊断为X综合征（典型心绞痛胸痛、运动试验异常、冠状动脉造影正常）的患者（11名女性，3名男性，平均年龄51±9.9岁）进行了跑步机运动试验（采用布鲁斯方案），分别在急性静脉输注氨茶碱（15分钟内总剂量6mg/kg）之前（基础状态）和之后进行。结果显示，尽管出现了心动过速，但氨茶碱通过提高缺血阈值延长了X综合征患者缺血发生前的时间，但对总运动持续时间没有影响。氨茶碱输注对运动诱发的胸痛也有有益作用。有人提出腺苷受体在X综合征的发病机制中可能起重要作用。
