通过基因组比较识别调控位点。

Recognition of regulatory sites by genomic comparison.

作者信息

Gelfand M S

机构信息

State Scientific Center for Biotechnology 'NIIGenetika', Moscow, Russia.

出版信息

Res Microbiol. 1999 Nov-Dec;150(9-10):755-71. doi: 10.1016/s0923-2508(99)00117-5.

DOI:10.1016/s0923-2508(99)00117-5

PMID:10673013

Abstract

Availability of complete bacterial genomes opens the way to the comparative approach to the recognition of transcription regulatory sites. Assumption of regulon conservation in conjunction with profile analysis provides two lines of independent evidence making it possible to make highly specific predictions. Recently this approach was used to analyze several regulons in eubacteria and archaebacteria. The present review covers recent advances in the comparative analysis of transcriptional regulation in prokaryotes and phylogenetic fingerprinting techniques in eukaryotes, and describes the emerging patterns of the evolution of regulatory systems.

摘要

完整细菌基因组的可得性为采用比较方法识别转录调控位点开辟了道路。调控子保守性的假设与图谱分析相结合，提供了两条独立的证据线，使得进行高度特异性的预测成为可能。最近，这种方法被用于分析真细菌和古细菌中的几个调控子。本综述涵盖了原核生物转录调控比较分析和真核生物系统发育指纹技术的最新进展，并描述了调控系统进化的新趋势。