3'-β-乙炔基和2'-脱氧-3'-β-乙炔基腺苷：腺苷脱氨酶的首批3'-β-支链腺苷底物。
3'-Beta-ethynyl and 2'-deoxy-3'-beta-ethynyl adenosines: first 3'-beta-branched-adenosines substrates of adenosine deaminase.
作者信息
Tritsch D, Jung P M, Burger A, Biellmann J F
机构信息
Laboratoire de Chimie Organique Biologique UMR 7509 du CNRS, Université Louis Pasteur, Faculté de Chimie, Strasbourg, France.
出版信息
Bioorg Med Chem Lett. 2000 Jan 17;10(2):139-41. doi: 10.1016/s0960-894x(99)00639-3.
The 3'-C-branched-adenosine and 2'-deoxyadenosine analogues 1-7 were tested as substrate of adenosine deaminase. The 9-(3'-C-ethynyl-beta-D-ribo-pentofuranosyl)adenine 1 and its 2'-deoxy analogue 7 were deaminated by the enzyme while the vinyl and ethyl derivatives 2 and 3 were not. The 9-(3'-C-branched-beta-D-xylo-pentofuranosyl)adenines 4-6 were deaminated by the deaminase.
对3'-C-支链腺苷和2'-脱氧腺苷类似物1-7进行了腺苷脱氨酶底物测试。9-(3'-C-乙炔基-β-D-核糖-戊呋喃糖基)腺嘌呤1及其2'-脱氧类似物7可被该酶脱氨，而乙烯基和乙基衍生物2和3则不能。9-(3'-C-支链-β-D-木糖-戊呋喃糖基)腺嘌呤4-6可被脱氨酶脱氨。
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