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Good response to cyclosporine therapy in patients with myelodysplastic syndromes having the HLA-DRB1*1501 allele.

作者信息

Okamoto T, Okada M, Yamada S, Takatsuka H, Wada H, Tamura A, Fujimora Y, Takemoto Y, Kakishita E

出版信息

Leukemia. 2000 Feb;14(2):344-6. doi: 10.1038/sj.leu.2401665.

DOI:10.1038/sj.leu.2401665
PMID:10673759
Abstract
摘要

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1
Good response to cyclosporine therapy in patients with myelodysplastic syndromes having the HLA-DRB1*1501 allele.携带HLA - DRB1*1501等位基因的骨髓增生异常综合征患者对环孢素治疗反应良好。
Leukemia. 2000 Feb;14(2):344-6. doi: 10.1038/sj.leu.2401665.
2
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Patients chosen for treatment with cyclosporine because of severe rheumatoid arthritis are more likely to carry HLA-DRB1 shared epitope alleles, and have earlier disease onset.因严重类风湿性关节炎而选择环孢素进行治疗的患者更有可能携带HLA-DRB1共享表位等位基因，且发病较早。
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The use of immunosuppressive therapy in MDS: clinical outcomes and their predictors in a large international patient cohort.MDS 中免疫抑制治疗的应用：大型国际患者队列的临床结局及其预测因素。
Blood Adv. 2018 Jul 24;2(14):1765-1772. doi: 10.1182/bloodadvances.2018019414.
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Immunomodulatory treatment of myelodysplastic syndromes: antithymocyte globulin, cyclosporine, and alemtuzumab.免疫调节治疗骨髓增生异常综合征：抗胸腺细胞球蛋白、环孢素和阿仑单抗。
Semin Hematol. 2012 Oct;49(4):304-11. doi: 10.1053/j.seminhematol.2012.07.004.
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Successful treatment using tacrolimus plus corticosteroid in a patient with RA associated with MDS.
他克莫司联合皮质类固醇成功治疗1例类风湿关节炎合并骨髓增生异常综合征患者。
Rheumatol Int. 2008 Mar;28(5):487-90. doi: 10.1007/s00296-007-0445-z. Epub 2007 Aug 29.
4
Response to cyclosporine therapy in patients with myelodysplastic syndrome: a clinical study of 12 cases and literature review.骨髓增生异常综合征患者对环孢素治疗的反应：12例临床研究及文献复习
Int J Hematol. 2004 Jul;80(1):35-42. doi: 10.1532/ijh97.04051.
5
Immunosuppressive therapy for myelodysplastic syndrome: efficacy of methylprednisolone pulse therapy with or without cyclosporin A.骨髓增生异常综合征的免疫抑制治疗：甲泼尼龙冲击疗法联合或不联合环孢素A的疗效
J Cancer Res Clin Oncol. 2003 Aug;129(8):485-91. doi: 10.1007/s00432-003-0477-z. Epub 2003 Jul 10.