Reddy J, Salkin L M
J Periodontol. 1976 Oct;47(10):607-10. doi: 10.1902/jop.1976.47.10.607.
The effectiveness of a commercially prepared oxygenating agent (Gly-Oxide Liquid) in reducing plaque accumulation and gingivitis was studied over a 3-week period. Sixty-nine dental students, ages 20 to 30, were divided into three groups: control (group I), placebo (group II), test formulation (group III). Subjects were scored using the Plaque and Gingival indices of Loe et al. at the beginning of the study and at 1, 2, and 3-week intervals. In accordance with a well-established experimental gingivitis model, oral hygiene was withdrawn for the duration of the study. No statistically significant differences in plaque development was noted. Analysis of variance showed a significant treatment effect on gingivitis (P less than 0.01). A significant difference between group I and group III was evident (P less than 0.05). The study indicates that the formulation may be effective in reducing gingivitis in human subjects. Additional investigations regarding its usefulness as a routine oral hygiene adjunct are warranted.
在为期3周的时间里，对一种市售的氧化制剂（Gly-Oxide液剂）减少牙菌斑积聚和牙龈炎的效果进行了研究。69名年龄在20至30岁之间的牙科专业学生被分为三组：对照组（第一组）、安慰剂组（第二组）、测试制剂组（第三组）。在研究开始时以及第1、2和3周时，使用Loe等人的菌斑指数和牙龈指数对受试者进行评分。根据一个成熟的实验性牙龈炎模型，在研究期间停止口腔卫生护理。未观察到菌斑形成有统计学上的显著差异。方差分析显示治疗对牙龈炎有显著效果（P小于0.01）。第一组和第三组之间有明显的显著差异（P小于0.05）。该研究表明，该制剂可能对减少人类受试者的牙龈炎有效。有必要对其作为常规口腔卫生辅助手段的效用进行进一步研究。
