Deinzer R, Kottmann W, Förster P, Herforth A, Stiller-Winkler R, Idel H
Institute for Medical Psychology, University of Düsseldorf, Germany.
J Clin Periodontol. 2000 Jan;27(1):74-7. doi: 10.1034/j.1600-051x.2000.027001074.x.
In a previous study, we found stress to increase crevicular interleukin-1beta (Il-1beta) secretion induced by supragingival plaque. While in that study, stress and plaque were presented concomitantly, we now wondered whether a consecutive presentation of these 2 factors would still exert stress effects.
39 medical students participated in the study; 18 took part in a major exam while the remaining 21 served as controls. From the day after the last exam, students neglected oral hygiene in 2 antagonistic quadrants for 21 days (experimental gingivitis), while they maintained perfect hygiene at the remaining sites. Crevicular fluid samples were taken at days 0, 5, 8, 15, 18, and 21 of experimental gingivitis.
A significant effect of pre-exposure to academic stress on crevicular Il-1beta concentration was found (area under the curve: p=0.042), the effect size, however, being smaller than in our previous study when stress and plaque were presented concomitantly.
It is concluded that pre-exposure to stress may persistently alter the immunological effects of microbial challenge to the periodontium.
在之前的一项研究中，我们发现应激会增加由龈上菌斑诱导的龈沟液白细胞介素-1β（IL-1β）分泌。在该研究中，应激和菌斑是同时出现的，我们现在想知道这两个因素相继出现是否仍会产生应激效应。
39名医学生参与了该研究；18名参加了一场重要考试，其余21名作为对照。从最后一场考试后的第二天起，学生们在两个相对象限忽视口腔卫生21天（实验性牙龈炎），而在其余部位保持良好的卫生状况。在实验性牙龈炎的第0、5、8、15、18和21天采集龈沟液样本。
发现预先暴露于学业应激对龈沟液IL-1β浓度有显著影响（曲线下面积：p = 0.042），然而，效应大小小于我们之前应激和菌斑同时出现时的研究。
得出的结论是，预先暴露于应激可能会持续改变微生物对牙周组织攻击的免疫效应。
