水溶液中N,N',N"-三亚乙基磷酰胺的降解：一项定性与动力学研究。

The degradation of N,N',N"-triethylenephosphoramide in aqueous solutions: a qualitative and kinetic study.

作者信息

van Maanen R J, Tijhof I M, Damen J M, Zwikker J W, Beijnen J H

机构信息

Department of Pharmaceutical Analysis, University of Utrecht, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands.

出版信息

Int J Pharm. 2000 Feb 25;196(1):85-94. doi: 10.1016/s0378-5173(99)00444-5.

DOI:10.1016/s0378-5173(99)00444-5

PMID:10675710

Abstract

The degradation of N,N',N"-triethylenephosphoramide (TEPA) in aqueous solutions has been investigated over a pH range of 3-14. Samples were analyzed using a gas chromatographic system with nitrogen/phosphorus selective detection. The degradation kinetics were studied as function of pH, sodium chloride concentration and temperature. The degradation of TEPA in buffers follows pseudo first order kinetics. The logk(obs)8 the methoxy derivative of TEPA was formed, as a consequence of the applied procedure.

摘要

在pH值为3至14的范围内，对水溶液中N,N',N"-三亚乙基磷酰胺（TEPA）的降解进行了研究。使用配备氮/磷选择性检测的气相色谱系统对样品进行分析。研究了降解动力学与pH值、氯化钠浓度和温度的关系。TEPA在缓冲溶液中的降解遵循准一级动力学。由于所采用的方法，形成了TEPA的甲氧基衍生物logk(obs)8。