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恰加斯病感染传播控制:巴西及拉丁美洲其他国家的输血传播情况

Chagas infection transmission control: situation of transfusional transmission in Brazil and other countries of Latin America.

作者信息

Moraes-Souza H

机构信息

Coordenação de Sangue e Hemoderivados, SPS, MS.

出版信息

Mem Inst Oswaldo Cruz. 1999;94 Suppl 1:419-23. doi: 10.1590/s0074-02761999000700083.

DOI:10.1590/s0074-02761999000700083
PMID:10677769
Abstract

The transmission of the transfusion-associated Chagas disease is an important mechanism of its dissemination in several Latin American countries. The transmission risk depends on five factors: prevalence of infection in blood donors, degree of serological coverage, sensibility of used tests, safety of obtained results and infection risk. The Southern Cone Iniciative set off by the Pan-American Health Organization, in 1991, is contributing to the implementation of blood law in each endemic country, and to reduce the risk of transfusional transmission of this horrible disease. Despite the clear improvement of Brasilian hemotherapy after 1980 (with the creation of the Blood National Program - Pró-Sangue) and the significant reduction of the chagasic infection among its blood donors; socio-economic, politic and cultural unlevels, prevent it from reaching the necessary universality and security. In order to assure both, the Brazilian Ministry of Health decided to restructure its blood system. In May, 1998, a great program was launched, to reach a specific goal: Blood - 100% with quality safety in all its process until 2003. It was divided in 12 projects, intends to guarantee the quality and self sufficiency in blood and hemoderivates.

摘要

输血相关恰加斯病的传播是其在几个拉丁美洲国家传播的重要机制。传播风险取决于五个因素:献血者感染率、血清学覆盖程度、所用检测的敏感性、检测结果的安全性以及感染风险。泛美卫生组织于1991年发起的南锥体倡议,正在推动每个流行国家实施血液法,并降低这种可怕疾病输血传播的风险。尽管1980年后巴西血液疗法有了明显改善(随着国家血液计划——献血计划的创建),且献血者中恰加斯病感染率大幅降低;但社会经济、政治和文化层面的不平衡,阻碍了其达到必要的普遍性和安全性。为确保这两点,巴西卫生部决定重组其血液系统。1998年5月,启动了一个重大计划,以实现一个特定目标:到2003年,血液在其所有过程中都达到100%质量安全。该计划分为12个项目,旨在确保血液及血液制品的质量和自给自足。

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J Venom Anim Toxins Incl Trop Dis. 2013 Dec 19;19(1):34. doi: 10.1186/1678-9199-19-34.
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BMC Infect Dis. 2008 Jan 16;8:5. doi: 10.1186/1471-2334-8-5.