阿夫唑嗪和多沙唑嗪十二指肠内给药对猫尿道压力的选择性作用。
Selective effects of alfuzosin and doxazosin with intraduodenal administration on urethral pressure of cats.
作者信息
Yang Z H, Ren L M, Wu Z J, Fu S X, Li Y S
机构信息
Department of Pharmacology, Hebei Medical University, Shijiazhuang, China.
出版信息
Zhongguo Yao Li Xue Bao. 1999 May;20(5):431-4.
AIM
To observe the selective effects of alfuzosin (Alf) and doxazosin (Dox) on the urethral pressure by different administration routes.
METHODS
The urethral pressure of the anesthetized cat was increased by electric stimulation of the hypogastric nerve. The different effects of Alf or Dox on the arterial blood pressure and urethral pressure between intraduodenal administration (i.d.) and intravenous infusion (i.v.) were compared.
RESULTS
When the hypogastric nerve was stimulated by electric stimulation (10 Hz, 25 V), the ratios of ED20(BP)/ED50(UP) i.d. to ED20(BP)/ED50(UP) i.v. were 10.9:4.3 for Alf, and 3.1:2.1 for Dox. The reduction in urethral pressure induced by i.d. Alf was greater than that by i.v. Alf. Dox did not show any difference in its effects by 2 administration routes.
CONCLUSION
Intraduodenal administration of Alf, but not Dox, selectively decreased the urethral pressure elevated by electric stimulation. The uroselectivity of i.d. Alf was not due to the species difference in its bioavailability and biotransformation.
目的
观察阿夫唑嗪（Alf）和多沙唑嗪（Dox）经不同给药途径对尿道压力的选择性作用。
方法
通过电刺激腹下神经提高麻醉猫的尿道压力。比较十二指肠内给药（i.d.）和静脉输注（i.v.）时Alf或Dox对动脉血压和尿道压力的不同影响。
结果
当以10Hz、25V电刺激腹下神经时，Alf的十二指肠内给药ED20（BP）/ED50（UP）与静脉输注ED20（BP）/ED50（UP）之比为10.9:4.3，Dox为3.1:2.1。十二指肠内给药Alf引起的尿道压力降低大于静脉输注Alf。Dox经两种给药途径的作用未显示出差异。
结论
十二指肠内给药Alf而非Dox可选择性降低电刺激升高的尿道压力。十二指肠内给药Alf的尿选择性并非因其生物利用度和生物转化的种属差异所致。
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