Romanelli F, Pomeroy C
Division of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington 40536, USA.
Pharmacotherapy. 2000 Feb;20(2):151-7. doi: 10.1592/phco.20.3.151.34777.
Antiretroviral drugs have significantly reduced death rates from the acquired immunodeficiency syndrome in the United States. They are highly effective in reducing viral replication, but their utility is threatened by rapid development of drug resistance. Although antiretroviral drug resistance testing is available by either genotyping or phenotyping, no consensus guidelines have been published regarding the appropriate use or interpretation of these new tests. Even though their role in clinical practice is not defined, it is important for clinicians to become familiar with relative advantages and disadvantages of genotypic and phenotypic testing and various mechanisms of antiretroviral resistance.
抗逆转录病毒药物显著降低了美国因获得性免疫缺陷综合征导致的死亡率。它们在减少病毒复制方面非常有效，但其效用受到耐药性快速发展的威胁。尽管可以通过基因分型或表型分析进行抗逆转录病毒药物耐药性检测，但关于这些新检测的适当使用或解读，尚未发布共识指南。即使它们在临床实践中的作用尚未明确，但临床医生熟悉基因分型和表型检测的相对优缺点以及抗逆转录病毒耐药性的各种机制很重要。
