与科尔萨科夫综合征患者相比，慢性酒精中毒患者的认知功能正常。
Normal cognitive performance in patients with chronic alcoholism in contrast to patients with Korsakoff's syndrome.
作者信息
Krabbendam L, Visser P J, Derix M M, Verhey F, Hofman P, Verhoeven W, Tuinier S, Jolles J
机构信息
Department of Psychiatry and Neuropsychology, Maastricht University and Psychomedical Center Vijverdal, The Netherlands.
出版信息
J Neuropsychiatry Clin Neurosci. 2000 Winter;12(1):44-50. doi: 10.1176/jnp.12.1.44.
This study investigated which cognitive deficits are associated with chronic alcoholism. Neuropsychological profiles and MRI brain structure volumes of 14 patients with Korsakoff's syndrome, 15 patients with chronic alcoholism, and 16 healthy control subjects were compared. The patients with alcoholism had a normal cognitive performance and normal brain structure volumes. The patients with Korsakoff's syndrome had performance deficits on tests of memory, visuoperceptual, and executive functions, as well as reduced brain structure volumes. The results suggest that the cognitive deficits cannot be ascribed to mere chronic consumption of alcohol. If cognitive deficits are present in patients with chronic alcoholism, this may point to an underlying brain disorder.
本研究调查了哪些认知缺陷与慢性酒精中毒相关。比较了14例柯萨科夫综合征患者、15例慢性酒精中毒患者和16名健康对照者的神经心理学特征及脑部MRI结构体积。酒精中毒患者的认知表现和脑结构体积正常。柯萨科夫综合征患者在记忆、视觉感知和执行功能测试中存在表现缺陷，且脑结构体积减小。结果表明，认知缺陷不能仅仅归因于长期饮酒。如果慢性酒精中毒患者存在认知缺陷，这可能表明存在潜在的脑部疾病。
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