Bogdan C, Röllinghoff M, Diefenbach A
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D-91054, Germany.
Curr Opin Immunol. 2000 Feb;12(1):64-76. doi: 10.1016/s0952-7915(99)00052-7.
Nitric oxide, nitric oxide derivatives and reactive oxygen intermediates are toxic molecules of the immune system which contribute to the control of microbial pathogens and tumors. There is recent evidence for additional functions of these oxygen metabolites in innate and adaptive immunity; these functions include the modulation of the cytokine response of lymphocytes and the regulation of immune cell apoptosis, as well as immunodeviating effects. Components of several signal transduction pathways have been identified as intracellular targets for reactive nitrogen and oxygen intermediates.
一氧化氮、一氧化氮衍生物和活性氧中间体是免疫系统的毒性分子，有助于控制微生物病原体和肿瘤。最近有证据表明，这些氧代谢产物在先天免疫和适应性免疫中具有其他功能；这些功能包括调节淋巴细胞的细胞因子反应、调节免疫细胞凋亡以及免疫偏离作用。几种信号转导途径的成分已被确定为活性氮和氧中间体的细胞内靶点。
